Evidence map›Paper›PMID 40353796›Full record

ArticleJournal of medicinal chemistry2025

Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite

Jean Dam, Grant A Boyle, André Horatscheck, John G Woodland, Claire Le Manach, Gurminder Kaur, Dale Taylor, Liezl Krugmann, Mathew Njoroge, Nina Lawrence and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jean DamHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0009-0002-6103-5920
Grant A BoyleHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0009-0005-7185-5203
André HoratscheckHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0001-6485-6391
John G WoodlandHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0001-6273-5596
Claire Le ManachHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0002-9310-0048
Gurminder KaurHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Dale TaylorHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Liezl KrugmannHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Mathew NjorogeHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Nina LawrenceHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Christel BrunschwigHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Victor ZdorichenkoDepartment of Chemistry, Arundel Building 305. School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex BN1 9RH, United Kingdom.
Brian CoxDepartment of Chemistry, Arundel Building 305. School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex BN1 9RH, United Kingdom.ORCID 0000-0002-5980-9707
Sergio WittlinSwiss Tropical and Public Health Institute, Kreuzstrasse 2, Allschwil 4106, Switzerland.ORCID 0000-0002-0811-0912
Thomas W von GeldernMedicines for Malaria Venture, ICC, Route de Pré-Bois 20, PO Box 1826, Geneva 1215, Switzerland.ORCID 0000-0002-0649-7885
Dennis SmithMedicines for Malaria Venture, ICC, Route de Pré-Bois 20, PO Box 1826, Geneva 1215, Switzerland.
James DuffyMedicines for Malaria Venture, ICC, Route de Pré-Bois 20, PO Box 1826, Geneva 1215, Switzerland.
Gregory S BasarabHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0001-5684-6046
Kelly ChibaleHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0002-1327-4727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the search for novel chemotypes with high sp

Indexed as

AntimalarialsIndolesPlasmodium falciparumSpiro CompoundsAnimalsHumansMalaria, FalciparumMiceMice, SCIDParasitic Sensitivity TestsPhenotypeStructure-Activity RelationshipAntimalarialsIndolesSpiro Compounds

Identifiers

PMID40353796
PMCPMC12105011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.