Evidence map›Paper›PMID 40353794›Full record

SynthesisOncotarget2025

Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis.

Rahaf Alchazal, Khaled J Zaitoun, Mohammad Al-Qudah, Ghena Zaitoun, Amira M Taha, Othman Saleh, Mohammad Alqudah, Mohammad Abuawwad, Mohammad Taha, Abdullah Yousef Aldalati

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rahaf Alchazal *Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Khaled J Zaitoun *Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mohammad Al-QudahFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Ghena ZaitounDepartment of Biology, Edmonds College, Lynnwood, WA 98036, USA.
Amira M TahaFaculty of Medicine, Fayoum University, Egypt.
Othman SalehFaculty of Medicine, Hashemite University, Amman, Jordan.
Mohammad AlqudahFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Mohammad AbuawwadFaculty of Medicine, Cairo University Kasr Alainy, Egypt.
Mohammad TahaFaculty of Medicine, Cairo University Kasr Alainy, Egypt.
Abdullah Yousef AldalatiFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer is a type of cancer that can affect both males and females, but it is widespread among women. Blood types may be associated with breast cancer, as many studies have reported on this relationship but rarely described it. The primary objective of our research is to summarize and analyze the available evidence to produce comprehensive and accurate information that can be used to make evidence-based decisions.

methodsResearchers searched for studies on breast cancer patients and ABO blood groups across four major databases: PubMed, Scopus, Web of Science, and Google. The outcomes of the studies were presented as a relative risk and odds ratio with a 95% confidence interval.

resultsTwenty-nine case-control studies with 13029 breast cancer patients. Blood type A was the most common blood type among patients. For blood type A, there was an association with breast cancer (OR = 1.18, 95% CI: 1.03-1.36). Blood types B, AB, and Rh factor showed no significant association with breast cancer (OR = 0.97, 95% CI: 0.86-1.11, OR = 1.05, 95% CI: 0.89-1.25, and OR = 1.14, 95% CI: 0.81-1.60 respectively) in compare to blood type A.

conclusionsThis study highlights the potential of blood type A as a risk factor for breast cancer compared to blood type O. This relationship was insignificant for blood types B, AB, or Rh. Further studies are needed to understand the mechanisms behind the blood type and breast cancer correlation.

Indexed as

ABO Blood-Group SystemBreast NeoplasmsRh-Hr Blood-Group SystemCase-Control StudiesFemaleHumansOdds RatioRisk FactorsABO Blood-Group SystemRh-Hr Blood-Group Systemblood group antigensbreast cancercancer risk factorstumor

Identifiers

PMID40353794
PMCPMC12068321

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.