Evidence map›Paper›PMID 40353686›Full record

ArticlemBio2025

Giant transposons promote strain heterogeneity in a major fungal pathogen.

Emile Gluck-Thaler, Adrian Forsythe, Charles Puerner, Cecilia Gutierrez-Perez, Jason E Stajich, Daniel Croll, Robert A Cramer, Aaron A Vogan

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Opportunistic pathogenicity in fungi can transcend species boundaries.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Emile Gluck-ThalerLaboratory of Evolutionary Genetics, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.ORCID 0000-0003-0438-7495
Adrian ForsytheSystematic Biology, Department of Organismal Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-1966-9946
Charles PuernerDepartment of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.ORCID 0000-0002-4402-0295
Cecilia Gutierrez-PerezDepartment of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.ORCID 0000-0002-9808-0701
Jason E StajichDepartment of Microbiology and Plant Pathology, University of California-Riverside, Riverside, California, USA.ORCID 0000-0002-7591-0020
Daniel CrollLaboratory of Evolutionary Genetics, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.ORCID 0000-0002-2072-380X
Robert A CramerDepartment of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.ORCID 0000-0001-5503-5006
Aaron A VoganSystematic Biology, Department of Organismal Biology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2013-7445

Funding

Evolution of Aspergillus fumigatus virulenceR01AI130128 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2017 to 2026
$4.5M
Acquisition of a Scalable Storage Cluster for Data Intensive NIH ResearchS10OD016290 · OD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GIRKE, THOMAS · 2014 to 2014
$593k
H2020 Marie Skłodowska-Curie Actions 890630National Science Foundation DBI-2215705NIAID NIH HHS R01 AI130128NIH HHS 2R01AI130128NIH HHS S10 OD016290NIH HHS S10-OD016290Svenska Forskningsrådet Formas 2019-01227Vetenskapsrådet 2021-04290
6 · The paper itself

Abstract

Fungal infections are difficult to prevent and treat in large part due to strain heterogeneity, which confounds diagnostic predictability. Yet, the genetic mechanisms driving strain-to-strain variation remain poorly understood. Here, we determined the extent to which

Indexed as

Aspergillus fumigatusDNA Transposable ElementsGenetic HeterogeneityGenetic VariationGenome, FungalHumansPhenotypeVirulence FactorsDNA Transposable ElementsVirulence FactorsAspergillosisAspergillus fumigatussecondary metabolismstrain heterogeneitytransposable elementtransposon

Identifiers

PMID40353686
PMCPMC12153272

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.