Evidence map›Paper›PMID 40353667›Full record

ArticleJournal of virology2025

IFNβ absence compensates for LAT functions in latency reactivation and T cell exhaustion.

Shaohui Wang, Ujjaldeep Jaggi, Jay J Oh, Homayon Ghiasi

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shaohui WangCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0001-7764-0581
Ujjaldeep JaggiCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jay J OhCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Homayon GhiasiCenter for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0003-3291-1995

Funding

The Role of gK in HSV-1 Induced Corneal ScarringR01EY013615 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2002 to 2026
$7.8M
Ocular HSV: Mechanism of virus reactivationR01EY029160 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2018 to 2026
$3.4M
Role of type 1 IFN in eye infectionR01EY033574 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2023 to 2026
$1.9M
NEI NIH HHS R01 EY013615NEI NIH HHS R01 EY029160NEI NIH HHS R01 EY033574NEI NIH HHS RO1EY029160NEI NIH HHS RO1EY033574
6 · The paper itself

Abstract

Type I interferons (IFNs) generate strong antiviral immunity following viral infection in mice and humans. These type I IFNs are encoded by at least 14 IFNα genes and a single IFNβ gene. We showed that the absence of one of the IFNα genes (IFNα2A

Indexed as

Herpes SimplexHerpesvirus 1, HumanInterferon-betaT-LymphocytesVirus ActivationVirus LatencyAnimalsEyeFemaleMiceMice, Inbred C57BLMice, KnockoutMicroRNAsT-Cell ExhaustionTrigeminal GanglionInterferon-betalatency associated transcript, herpes simplex virus-1MicroRNAsCD8exhaustioneye diseaseIFNβknockoutlatencyocular infectionPD-1reactivationtype 1 interferonvirus replication

Identifiers

PMID40353667
PMCPMC12172465

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.