Diaphragm Function in Very Preterm Infants at 36 Weeks' Postmenstrual Age.

Benjamin Stoecklin, Zeena Al-Obaidi, Jenny Svedenkrans, Raffaele Dellacà, J Jane Pillow

Abstract readObservational Study

In one paragraph

Observational study in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Benjamin StoecklinSchool of Human Sciences, University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0003-0021-0262

Zeena Al-ObaidiMedical School, University of Western Australia, Perth, Western Australia, Australia.

Jenny SvedenkransDepartment of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6194-5118

Raffaele DellacàDipartimento di Elettronica, Informazione e Bioingegneria-DEIB, Politecnico di Milano University, Milan, Italy.ORCID https://orcid.org/0000-0002-3672-4591

J Jane PillowSchool of Human Sciences, University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-6500-0138

Funding

All phases of this study were supported by the University of Western Australia and the Women and Newborn Health Service of Western Australia. Funded by National Health and Medical Research Council (NHMRC) of Australia (GNT1047689, GNT1057514) and the Metropolitan Health Research Infrastructure Fund (MHRIF). Dr Stoecklin was supported by the Swiss National Science Foundation (P2BSP3_158837) and a Research Training Program scholarship, The University of Western Australia. Dr Svedenkrans was supported by The Swedish Society of Medicine, The Samaritan Foundation, The Princess Lovisa Memory Foundation, The Society of Child Care (Sällskapet Barnavård), and The Fernstrom Foundation. Prof Pillow was supported by a NHMRC Senior Research Fellowship (RF1077691).

6 · The paper itself

Abstract

objectivesUnderstand how bronchopulmonary dysplasia (BPD) and antenatal and postnatal factors influence diaphragmatic functional effectiveness in very preterm infants. WORKING HYPOTHESIS: Diaphragmatic functional effectiveness during spontaneous breathing is impaired in infants with BPD. Moreover, diaphragmatic functional effectiveness is influenced by adverse antenatal and postnatal factors. METHODOLOGY: Diaphragmatic functional effectiveness was assessed in a single-centre, prospective observational study in preterm infants. Transdiaphragmatic pressure (Pdi) and respiratory flow were measured during quiet sleep at 36 weeks' postmenstrual age (PMA). Pdi was normalized to tidal volume (Pdi/V

resultsVery preterm infants (n = 182) were measured at a median (IQR) 35.6 (1.3) weeks' PMA. Infants with BPD had a lower Pdi/V

conclusionsContrary to our hypothesis, diaphragm functional effectiveness appears improved in infants with BPD. We speculate this finding may reflect an adaptive process, or alternatively indicate an increased recruitment of accessory muscles to achieve required ventilation in BPD infants. Adverse antenatal and postnatal factors only explain a small proportion of variance in diaphragm effectiveness.

Indexed as

Bronchopulmonary DysplasiaDiaphragmInfant, Extremely PrematureInfant, PrematureFemaleGestational AgeHumansInfant, NewbornMaleProspective StudiesTidal Volumebronchopulmonary dysplasiaprematurityrespiratory muscle function

Identifiers

PMID40353622

DOI10.1002/ppul.71121

PMCPMC12068034

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