Evidence map›Paper›PMID 40353521›Full record

ArticleJournal of dental research2025

Durable Dentin Bonding with Multifunctional Methacrylated Proanthocyanidins.

V Hass, N Wickerhauser, N Desch, Y Li, R Wang, Z Peng, Y Wang

Abstract read
In one paragraph

Article in Journal of dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Enhancing dentin bonding with catechol-based monomers by tailoring photoinitiator systems to overcome radical inhibition.Dental materials : official publication of the Academy of Dental Materials · 2026
    Article
  2. Antibacterial effect of a dental adhesive containing SCH-79797 onFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

V HassSchool of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.ORCID 0000-0002-4581-1291
N WickerhauserSchool of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.
N DeschSchool of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.
Y LiSchool of Science and Engineering, University of Missouri-Kansas City, Kansas City, MO, USA.
R WangSchool of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.ORCID 0000-0002-1607-8094
Z PengSchool of Science and Engineering, University of Missouri-Kansas City, Kansas City, MO, USA.
Y WangSchool of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.ORCID 0000-0002-2862-5075

Funding

Development of multifunctional resins for robust dentin bondingR01DE027049 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI WANG, YONG · 2018 to 2022
$1.8M
NIDCR NIH HHS R01 DE027049
6 · The paper itself

Abstract

The degradation of dentin bonding interfaces by enzymes, either originating from the dentin matrix or produced by oral biofilms, contributes to the failure of composite restorations. Proanthocyanidins (PAs) are effective collagen crosslinkers that help preserve collagen, but their interference with adhesive polymerization impairs clinical applications. Methacrylate-functionalized PA (MAPA) was developed as a polymerizable collagen crosslinker, designed to strengthen collagen while copolymerizing with adhesives. This study evaluated the effects of MAPA-containing adhesives on dentin-bonding properties, including collagen crosslinking within bonding interfaces (via sodium dodecyl sulfate-collagen hybridizing peptide assay), microtensile bond strength (µTBS), and collagenolytic activity (in situ zymography) at 24 h and after 2 y (2Y), as well as on biofilm inhibition. Two adhesives, Scotchbond Universal and Prime&Bond Elect, were modified with MAPA or PA at 0%, 5%, and 10% concentrations. Human molar dentin surfaces were bonded and restored using composite resin, then sectioned into sticks or slabs for µTBS and in situ zymography at 24 h or 2Y. Additional specimens were evaluated for biofilm formation (

Indexed as

Dental BondingDentinDentin-Bonding AgentsMethacrylatesProanthocyanidinsBiofilmsBisphenol A-Glycidyl MethacrylateCollagenComposite ResinsCross-Linking ReagentsDental Stress AnalysisHumansMaterials TestingPolymethacrylic AcidsResin CementsStreptococcus mutansBisphenol A-Glycidyl MethacrylateCollagenComposite ResinsCross-Linking ReagentsDentin-Bonding AgentsMethacrylatesPolymethacrylic AcidsPrime & BondProanthocyanidinsResin CementsScotchbondadhesivebiofilmchemical bondingcollagencrosslinkingmatrix metalloproteinase

Identifiers

PMID40353521
PMCPMC13474040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.