Evidence map›Paper›PMID 40353511›Full record

ArticleJournal of psychopharmacology (Oxford, England)2025

Maike Scherf-Clavel, Heike Weber, Carolin Weiß, Catherina Klüpfel, Saskia Stonawski, Leif Hommers, Stefan Unterecker, Katharina Domschke, Andreas Menke, Sarah Kittel-Schneider and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maike Scherf-ClavelDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.ORCID 0000-0002-4780-612X
Heike WeberDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Carolin WeißDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.ORCID 0000-0001-7519-2455
Catherina KlüpfelDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Saskia StonawskiDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Leif HommersDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Stefan UntereckerDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Katharina DomschkeFaculty of Medicine, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.
Andreas MenkeDepartment of Psychosomatic Medicine, and Psychotherapy, Medical Park Chiemseeblick, Bernau am Chiemsee, Germany.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Sebastian WaltherDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Jürgen DeckertDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Angelika Erhardt-LehmannDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPsychopharmacotherapy with mirtazapine is commonplace. Lower serum concentrations of mirtazapine were reported in smokers due to

aimWe aimed to investigate the association of

methodsTwo depression cohorts were investigated for the association between serum concentration and treatment response of mirtazapine and

resultsDose-corrected serum concentration (CD) of mirtazapine was associated with smoking status, sex, and age, with lower CD in smokers, females, and older patients. Considering non-smokers and genotype-grouped smokers, CD of mirtazapine in DISCUSSION: As yet, for clinical practice, it may be more relevant to focus on smoking status than on the

Indexed as

Antidepressive Agents, TricyclicCytochrome P-450 CYP1A2MirtazapineSmokingAdultAgedCohort StudiesFemaleGenotypeHumansMaleMiddle AgedSex FactorsTreatment OutcomeAntidepressive Agents, TricyclicCYP1A2 protein, humanCytochrome P-450 CYP1A2MirtazapineCYP1A2Mirtazapinepharmacogeneticsserum concentrationsmoking cigarettes

Identifiers

PMID40353511
PMCPMC12287552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.