ArticleCurrent radiopharmaceuticals2025
Evaluating the Effectiveness of Geant4 Software in Measuring the Damage Caused by Ti48 Ion Radiation on Nerve Cells, in Comparison to the Biophysical Model and Empirical Data.
Article in Current radiopharmaceuticals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPresently, heavy particle ion radiation therapy is commonly utilized for the treatment of deep-seated malignancies, such as brain tumors. In addition to tumor treatment, these particles may negatively impact healthy nerve cells. Therefore, it is essential to investigate the radiobiological effects of these radiations on cells. Simulation studies that model the radiation of heavy particles and the exact geometrical configuration of nerve cells are essential and effective in evaluating potential cellular damage.
methodsThe NEURON software was employed in Geant4 code to simulate an individual nerve cell (ID no: NMO 06176) and a network of ten neural cells subjected to bombardment by Ti48 ion particles at an energy of 600 MeV/u.
resultsThe absorbed energy differs among several components of individual cells and neural networks, including the soma and dendrites. The absorbed doses from Ti48 radiation in individual nerve cells and dendritic networks surpass those in the cell body, and this ratio remains consistent as the dosage escalates. The decrease in the initial length of dendrites in both individual cells and neuronal networks intensifies with increased dosages. ; Discussion: The simulation results demonstrate that dendrites absorb a higher radiation dose than the soma, resulting in greater structural damage. This finding highlights the vulnerability of neuronal networks to high-LET radiation, with important implications for space radiation protection and clinical radiotherapy planning.
conclusionThe diminution of dendritic length due to Ti48 radiation is more significant within the cellular network compared to isolated nerve cells.
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