Evidence map›Paper›PMID 40353369›Full record

ReviewAmerican journal of physiology. Cell physiology2025

Stromal heterogeneity in the adult lung delineated by single-cell genomics.

Tatsuya Tsukui, Dean Sheppard

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Beyond the epithelium: multicellular niches in lung regeneration and disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tatsuya TsukuiDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California, San Francisco, California, United States.ORCID 0000-0003-3100-6934
Dean SheppardDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California, San Francisco, California, United States.ORCID 0000-0002-6277-2036

Funding

Induction, fate and function of inflammatory fibroblastsR01HL171159 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dean Sheppard · 2024 to 2026
$2.3M
American Lung Association (ALA) HIA-1278193HHS | NIH | NHLBI | Division of Intramural Research (DIR) HL142568HHS | NIH | NHLBI | Division of Intramural Research (DIR) HL155786NHLBI NIH HHS R01 HL171159
6 · The paper itself

Abstract

Stromal cells in the lung provide structural support to other cells and play critical roles in inflammation, repair, and fibrosis after injury. Recent technological advancements in single-cell genomics have tremendously improved our knowledge of stromal heterogeneity in the lung. Stromal heterogeneity in single-cell RNA sequencing data is often conserved across different studies despite the different annotation strategies. Spatial analyses suggest that each stromal subset is characterized by unique anatomic locations in the adult lung. This review overviews the stromal heterogeneity delineated by single-cell RNA sequencing studies and highlights the functional characteristics and locations of each population.

Indexed as

GenomicsLungSingle-Cell AnalysisStromal CellsAnimalsHumansfibroblastfibrosisinjurylungstromal cell

Identifiers

PMID40353369
PMCPMC13134367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.