ArticlePlastic and reconstructive surgery. Global open2025
Combined Effect of Low-level Laser Therapy and Hyaluronic Acid Injection in Oral Wound Healing: An Experimental Study.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Topical hyaluronic acid serum, oral vitamin C, and their combined regimen modulate collagen-related repair indices in a sutured primary-intention rat incisional wound model.Journal of molecular histology · 2026Article
- Plant Exosome Injections in Tongue Wounds: A Comparative Histological and Immunohistochemical Experimental Study.Plastic and reconstructive surgery. Global open · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the effect of low-level laser therapy and hyaluronic acid injection in intraoral wound healing. Eighteen Wister albino rats were included in this study, and they were randomly divided into 3 groups; in the first group, a wound was created with a 450-nm diode laser in the buccal mucosa without any further intervention, and in the second group, the wound was created with a 450-nm diode laser followed by non-cross-linked hyaluronic acid injection. In the third group, the wound was created with a 450-nm diode laser followed by low-level laser therapy with a 650-nm diode laser and hyaluronic acid injection. Biopsies were taken at different intervals (baseline, third day, and seventh day) for evaluation of the wound healing using hematoxylin stain, Masson trichrome stain, and immunohistochemical study for CD34 analysis. Group 3 showed significant results compared with the other groups on the third and seventh postoperative days, with increased collagen production and better tissue organization with abundant angiogenesis. Low-level laser therapy in addition to hyaluronic acid injection in incisions created with lasers shows promising results in wound healing and may quicken the healing process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.