Evidence map›Paper›PMID 40353184›Full record

ArticleHepatoma research2024

Liver injury and recovery following radiation therapy for hepatocellular carcinoma: insights from functional liver imaging.

Peter Zaki, Kanokphorn Thonglert, Smith Apisarnthanarax, Clemens Grassberger, Stephen R Bowen, Joseph Tsai, Jonathan G Sham, Bing-Hao Chiang, Matthew J Nyflot

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatoma research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter ZakiDepartment of Radiation Oncology, University of Washington, Seattle, WA 98195, USA.
Kanokphorn ThonglertDepartment of Radiology, Division of Radiation Oncology, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red C Society, Bangkok 10330, Thailand.
Smith ApisarnthanaraxDepartment of Radiation Oncology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-4522-8300
Clemens GrassbergerDepartment of Radiation Oncology, University of Washington, Seattle, WA 98195, USA.
Stephen R BowenDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.
Joseph TsaiDepartment of Radiation Oncology, University of Washington, Seattle, WA 98195, USA.
Jonathan G ShamDepartment of Surgery, University of Washington, Seattle, WA 98195, USA.
Bing-Hao ChiangDepartment of Radiation Oncology, University of Washington, Seattle, WA 98195, USA.
Matthew J NyflotDepartment of Radiology, University of Washington, Seattle, WA 98195, USA.

Funding

A generalizable model of normal tissue recovery to enable personalized re-irradiationR21CA292207 · NCI · UNIVERSITY OF WASHINGTON · PI GRASSBERGER, CLEMENS · 2024 to 2024
$400k
NCI NIH HHS R21 CA292207
6 · The paper itself

Abstract

Aim: A critical need for hepatocellular carcinoma (HCC) management is understanding how the liver recovers following radiotherapy (RT). We hypothesized that functional liver imaging with Methods: The liver function of patients with HCC was assessed using Results: Of 31 patients with evaluable post-RT SC SPECT/CT scans (total of 32), 23 had pre-treatment Child-Pugh (CP)-A and 9 had CP-B/C scores. The median follow-up post-RT was 57 days. The median change in ALV was -1.7% with no significant difference between CP-A and CP-B/C patients ( Conclusion: Functional imaging provides additional information regarding liver injury and recovery following RT that conventional imaging cannot reveal. Patients with CP-A liver status showed less decline following RT and most had liver function near or above pre-treatment levels.

Indexed as

child-pughHCCIMRTproton therapyrecoveryreirradiationSBRTSPECT

Identifiers

PMID40353184
PMCPMC12064179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.