Evidence map›Paper›PMID 40353180›Full record

ArticleSurgical neurology international2025

Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literature.

Molly Butler, Christopher Carr, Mehul Mehra, Anne Marie Barnett, Jacey Salley, Ayushi Chauhan, Sami Belakhlef, Gerald C Wallace Iv, Martin Rutkowski, John Vender and 1 more

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In one paragraph

Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Molly ButlerMedical College of Georgia at Augusta University, Augusta, Georgia, United States.
Christopher CarrDepartment of Neurosurgery, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Mehul MehraDepartment of Neurosurgery, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Anne Marie BarnettDepartment of Endocrinology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Jacey SalleyDepartment of Neurology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Ayushi ChauhanDepartment of Hematology/Oncology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Sami BelakhlefDepartment of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Gerald C Wallace IvDepartment of Neurology and Oncology, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Martin RutkowskiDepartment of Neurosurgery, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
John VenderDepartment of Neurosurgery, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.
Fernando L ValeDepartment of Neurosurgery, Medical College of Georgia at Augusta University, Augusta, Georgia, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary pituitary lymphomas are uncommon neoplasms that are typically derived from a B-cell lineage. Extranodal natural killer (NK)/T-cell lymphoma is distinct from B- and T-cell lymphomas and is associated with Epstein-Barr virus infection. Primary central nervous system (CNS) presentations of this neoplasm are exceptionally rare. Here, we report the case of extranodal NK/T-cell lymphoma presenting as a pituitary mass and review the literature related to this rare clinical entity. Case Description: A 31-year-old previously healthy male presented with 2 weeks of progressive headaches and ophthalmoplegia. Imaging revealed a large intrasellar mass with retroclival extension and involvement of the sphenoid and cavernous sinuses. An endoscopic biopsy of the sphenoidal mucosa was performed, and pathological examination was consistent with extranodal NK/T-cell lymphoma. Despite treatment with chemo- and radiotherapy, the patient died approximately 8 months after initial presentation due to systemic disease progression with multiorgan failure. Conclusion: The presentation of extranodal NK/T-cell lymphoma as a pituitary lesion is very rare, having been reported only twice in the previous literature. Patients with primary CNS extranodal NK/T-cell lymphoma typically experience an aggressive clinical course with a poor prognosis, as in our case.

Indexed as

BiopsyHeadacheNeoplasmsOphthalmoplegiaT-lymphocytes

Identifiers

PMID40353180
PMCPMC12065498

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