ArticleNeuropsychiatric disease and treatment2025
Potential Value of Plasma-Based Biomarkers for Prediction of Episodic Memory Performance and Identification of Individuals with Amnestic Mild Cognitive Impairment.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Patients with amnestic mild cognitive impairment (aMCI) are thought to be highly susceptible to developing Alzheimer's disease (AD). The study aimed to investigate the possibilities of plasma-biomarkers for individual patient identification of aMCI and prediction of episodic memory. Methods: We recruited 87 healthy controls and 68 aMCI patients in this study; and 22/68 aMCI patients completed 3-year follow-up visits, with six aMCI patients converting to AD. An ultrasensitive quantitative method was employed to measure the levels of plasma biomarkers. Results: Relative to healthy controls, the aMCI patients showed significantly higher levels of plasma neurofilament light (NfL) and lower levels of plasma Conclusion: We provided support to the use of plasma total-tau and NfL as simple biomarkers to predict the severity of episodic memory deficit for individual aMCI patients and aMCI progression, and further demonstrated that the combination of plasma
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