ReviewNature and science of sleep2025
What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control.
Review in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Pollution-Induced Allergy Skews Metabolism Toward Obesity-A Conceptual Review.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain (NP), arising from lesions or diseases of the sensory nervous system, significantly disrupts sleep, creating a feedback loop where pain and sleep disturbances exacerbate each other. Research suggests that sleep disruption may contribute to progressing from acute to chronic NP. The neural circuits involved in sleep-wake regulation and pain processing are intricately interconnected, making it difficult to pinpoint the specific regions responsible for each function. This review seeks to disentangle these complex relationships by providing a detailed overview of the anatomical pathways involved in NP, extending from the peripheral to the central nervous system. Additionally, it examines the neurocircuits that govern sleep-wake cycles and their interaction with pain pathways. By illuminating these connections, this review aims to deepen our understanding of how sleep influences NP, ultimately guiding the development of more effective strategies for managing NP and its associated sleep disturbances to improve the quality of life for those affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.