Evidence map›Paper›PMID 40352877›Full record

ArticleIndian journal of nephrology

The Prevalence and Outcomes of BK Polyoma Virus Nephropathy in Living Donor Kidney Transplant Recipients.

Abhyudaysingh Rana, Shyam Bihari Bansal, Camille Nelson Kotton, Amit Kumar Mahapatra, Alka Rana, Sidharth Kumar Sethi, Pranaw Kumar Jha, Ashwini B Gadde, Manish Jain, Dinesh Kumar Yadav and 2 more

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In one paragraph

Article in Indian journal of nephrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abhyudaysingh RanaDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.
Shyam Bihari BansalDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-8665-8588
Camille Nelson KottonInfectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA.ORCID https://orcid.org/0000-0001-7320-2234
Amit Kumar MahapatraDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-7727-8831
Alka RanaDepartment of Pathology and Laboratory Medicine, Medanta The Medicity, Gurugram, Haryana, India.
Sidharth Kumar SethiDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.
Pranaw Kumar JhaDepartment of Nephrology, Arihant Multispeciality Hospital, Nagpur, Maharashtra, India.
Ashwini B GaddeDepartment of Nephrology and Kidney Transplant, Fortis Memorial Hospital, Gurugram, Haryana, India.
Manish JainDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.
Dinesh Kumar YadavDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.
Dinesh BansalDepartment of Nephrology and Renal Transplant Medicine, Medanta-The Medicity, Gurugram, Haryana, India.
Vijay KherEpitome Kidney Urology Institute & Lions Hospital, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: BK polyomavirus nephropathy (BKPyVN) remains an important cause of allograft dysfunction and loss. There is little data about prevalence and outcome of BKPyVN infection from India in living donor kidney transplant recipients. Materials and Methods: This is a retrospective analysis of all biopsy-proven BKPyVN among kidney transplant recipients at our center from January 2010 to January 2022. We compared them to age, sex, and type of immunosuppression received matched (1:2) non-BKPyVN-infected recipients transplanted during the same period. Results: During the study period, 2465 patients underwent kidney transplants at our center, of which 26 (1.05%) developed biopsy-proven BKPyVN. Four recipients (16%) lost their graft over a median period of 65 (IQR, 57-83) months from the time of diagnosis. The mean serum creatinine at the recent follow-up was higher in the BKPyVN arm as compared to controls (2.05 ± 1.39 vs 1.35 ± 0.46, p = 0.001.) Both BKPyVN and control arms had similar death-censored graft survival (82% vs 94%, p = 0.09) and patient survival (88% vs 96%, p = 0.184). Conclusion: BKPyVN was uncommon in our kidney transplant recipients. Most patients were able to maintain their kidney function for many years, albeit at a somewhat reduced level compared with the controls, and about a fifth of our patients lost their graft.

Indexed as

BK virus nephropathyIndiaKidney transplantLiving donorPost-transplant viral infection

Identifiers

PMID40352877
PMCPMC12065578

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