Evidence map›Paper›PMID 40352820›Full record

ArticlePrecision nutrition2024

Integration of proteomics with prospective birth cohort to elucidate early life origins of cardiometabolic diseases: rationale, study design, lab assay, and quality control.

Xiumei Hong, Richard Xu, Michael Y Mi, Laurie A Farrell, Guoying Wang, Liming Liang, Robert E Gerszten, Frank B Hu, Xiaobin Wang

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Precision nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Richard XuDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Michael Y MiDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Laurie A FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Frank B HuDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Research Infrastructure for the Hopkins Population CenterR24HD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HAO, LINGXIN · 2003 to 2017
$5.1M
Immune Development Across the Life Course: Integrating Exposures and Multi-Omics in the Boston Birth CohortU01ES034983 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Hongkai Ji, Harry Benjamin Larman · 2022 to 2026
$3.9M
The Hopkins Population CenterP2CHD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI FEINIAN CHEN · 2021 to 2026
$3.0M
Inter-generational Link of Cardio-Metabolic Risk: Integrate Multi-OMICs with Birth CohortR01HD098232 · NICHD · JOHNS HOPKINS UNIVERSITY · PI LIANG, LIMING, WANG, XIAOBIN · 2019 to 2022
$2.7M
Population Neuroscience of Aging and Alzheimer's Disease (PNA)T32AG055381 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano, Andrea L Rosso · 2018 to 2026
$2.7M
Functional RNA Modifications, Micronutrient Exposure, Developmental DisabilitiesR01ES031521 · NIEHS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, XIAOBIN, XIE, HEHUANG · 2020 to 2024
$1.9M
Maternal Exposure to Low Level Mercury, Metabolome, and Child Cardiometabolic Risk in Multi-Ethnic Prospective Birth CohortsR01ES031272 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI WANG, GUOYING, WANG, XIAOBIN · 2020 to 2024
$1.2M
Mixed meal tolerance test elicited metabolite responses as novel markers of cardiometabolic riskK23HL171855 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Michael Mi · 2024 to 2026
$572k
Maternal and Cord Blood Metabolome, Infant Feeding, and Development of Food Allergy in a Prospective Birth CohortR21AI154233 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HONG, XIUMEI · 2020 to 2021
$450k
Interplay of the T Cell Repertoire Development and Early Life Exposure on Incident Risk of Peanut AllergyR21AI171059 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HONG, XIUMEI, SMITH, KELLIE NICOLE · 2023 to 2024
$450k
NHLBI NIH HHS K23 HL171855NIAID NIH HHS R21 AI154233NIAID NIH HHS R21 AI171059NIA NIH HHS T32 AG055381NICHD NIH HHS P2C HD042854NICHD NIH HHS R01 HD041702NICHD NIH HHS R01 HD098232NICHD NIH HHS R24 HD042854NIEHS NIH HHS R01 ES031272NIEHS NIH HHS R01 ES031521NIEHS NIH HHS U01 ES034983
6 · The paper itself

Abstract

There is growing evidence that the plasma proteome provides insights into personal health status at different stages of life. However, limited data are available on high-throughput proteomic studies in pediatric populations, especially, using prospective birth cohorts. We launched a proteomics study in 990 children from a US predominantly urban, low-income, multi-ethnic prospective Boston Birth Cohort (BBC, referred as "BBC proteomics study"), which aimed to leverage proteomics to investigate the biological pathways underlying the link between preterm birth and child long-term cardiometabolic health. The objective of this paper is to describe the rationale, study design, proteomic assay and quality control steps for the BBC proteomics study in a subset of children with available proteomic profiling. Using the OLINK

Identifiers

PMID40352820
PMCPMC12061434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.