ArticleFrontiers in genetics2025
Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The 200 most influential publications in migraine research: a bibliometric mapping of the intellectual landscape.Frontiers in neurology · 2025Pooled it
- Chronic Ocular Surface Pain: A Missing Member of the Chronic Overlapping Pain Conditions?Drugs · 2026Review
- Association between TNFa rs1800629 and migraine: Case-control study and updated meta-analysis.AIMS neuroscience · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Migraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population. Methods: The research analyzed specific genetic variations-TNF-α -308 G/A, TNF-α -857 C/T, TNF-α -238G/A, IL1B-3953 C/T, and IL1RN -2018T/C SNPs-within 212 migraine patients and 210 healthy controls. Utilizing SNaPshot technology, scientists genotyped these markers related to TNF-α and IL-1 genes. Results: Findings revealed a significant association between the IL1B-3953 C/T SNP and migraine susceptibility, particularly noting its link with a familial history of the disorder. The presence of the C allele at this location was more prevalent in migraine sufferers. Multivariate analysis reinforced this connection, indicating the C allele under a dominant model as an independent risk factor for migraine (OR = 2.315, 95%CI: 1.053-5.090, P = 0.037). Additionally, the study observed a sex-specific difference regarding the TNF-α -857 C/T SNP among migraine patients. Conclusion: Overall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B-3953 C/T SNP as a potential biomarker for migraine susceptibility.
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