ReviewFrontiers in neurology2025
Biological effect of acupuncture on peripheral facial paralysis.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- The efficacy and safety of acupuncture treatment for peripheral facial paralysis: an overview of systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Comparison of acupuncture intervention from the acute phase or the non-acute phase in patients with peripheral facial paralysis: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Time to Complete Clinical Recovery and Its Predictors in Bell's Palsy Patients Receiving Acupuncture: A Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Efficacy of intradermal acupuncture for ocular surface diseases secondary to refractory peripheral facial palsy: a randomized controlled trial study protocol.Frontiers in medicine · 2026Article
- Peripheral facial palsy: contemporary advances and unresolved debates in management from pathogenic mechanisms to tailored reconstruction.Frontiers in neurology · 2026Review
- Does acute-phase acupuncture at Hegu (LI04) promote facial nerve regeneration and upregulation of the PI3K/Akt/mTOR pathway? A hypothesis-generating study in a rabbit crush injury model.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral facial paralysis is the dominant treatment disease of acupuncture. A large number of studies have proved the effectiveness of acupuncture in the treatment of peripheral facial paralysis. However, the underlying biological effect remains in an exploratory phase. This article will sort out and summarize the existing research mechanisms from the following aspects: inflammatory response, immune regulation, neurotransmitters, immune response, facial microcirculation, oxidative stress, changes in nerve structure and function, specificity of acupoints, acupuncture intervention time, and other potential mechanisms aiming to provide a scientific foundation for the role of acupuncture in the treatment of peripheral facial paralysis. Furthermore, the review discusses future directions for mechanistic research based on existing findings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.