ArticleCrystal growth & design2025
Impact of the Coformer Carbon-Chain Length on the Properties of Haloperidol Pharmaceutical Salts.
Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haloperidol (HAL) is a conventional antipsychotic drug with poor aqueous solubility, which is associated with a major risk of side effects. In this context, crystal engineering has provided an efficient approach for tuning the physicochemical properties of active pharmaceutical ingredients (APIs). However, there is a huge lack of knowledge about how coformer molecules impact the pharmaceutical properties of the multicomponent materials, with special attention to solubility and stability. To this purpose, five novel salts and three ionic cocrystals were synthesized using HAL and a series of closely related dicarboxylic acid counterions. Mechanochemical strategies were applied for synthesis, while thermal, spectroscopic, and X-ray diffraction techniques were used for a complete characterization of the materials. By understanding the relationships between the crystal structures and the final properties, this research seeks to inform the rational design of HAL multicomponent drugs, providing a framework for improving the performance of not only HAL but also other APIs with similar challenges.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.