ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Diabetes and cortical thickness in ethnically diverse cognitively normal older adults.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Glymphatic dysfunction is associated with hyperglycemia-related cortical thinning in patients with type 2 diabetes mellitus.Journal of endocrinological investigation · 2026Article
- Race and Ethnicity, Hypertension, and Neuroimaging Markers of Brain Aging: A Causal Mediation Analysis in the HABS-HD Study.Neurology · 2026Article
- Evaluation of physical functioning as a marker of brain imaging outcomes in a multiethnic community-based cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70 years old.BMC medicine · 2025Article
- Sleep macro-architecture, nocturnal hypoxemia, and Alzheimer's disease-related MRI patterns among diverse older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Diabetes and cortical thickness in ethnically diverse cognitively normal older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Eligibility for anti-amyloid treatment in a multiethnic community-based study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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15 authors.
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Abstract
introductionMechanisms linking type 2 diabetes mellitus (T2DM) with dementia are poorly understood. We examined T2DM associations with cortical thickness and hippocampal volume in ethnoracially diverse, cognitively unimpaired older adults.
methodsIn 2171 cognitively unimpaired older adults, we examined (1) how T2DM related to cortical thickness and hippocampal volume, (2) whether associations were independent of socioeconomic factors and comorbidities, (3) whether associations were driven by hyperglycemia or hyperinsulinemia, and (4) how associations varied by self-reported race/ethnicity.
resultsT2DM was correlated with thinner cortex independent of socioeconomic factors and comorbidities, and this was driven by higher hemoglobin A1c (HbA1c). Higher HbA1c levels were correlated with thinner cortex in diabetics and non-diabetics. T2DM-cortical thickness associations were strong and widespread in Hispanic participants, modest and limited to temporal regions in non-Hispanic White participants, and not present in non-Hispanic Black adults. DISCUSSION: T2DM is associated with a thinner cortex, and this is driven by poor glycemic control. Highlights: T2DM is associated with a thinner cortex.The T2DM-cortical thickness relationship is likely driven by poor glucose control.Higher HbA1c levels correlated with thinner cortex in diabetics and non-diabetics.The T2DM-cortical thickness association varied by self-reported ethnicity/race.
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