ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Beyond amyloid: Contributions of neuroinflammation, cerebrovascular disease, and neurodegeneration to memory impairment in the oldest-old, the LifeAfter90 Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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19 authors.
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Abstract
introductionNeuroinflammation may have sex-specific effects on white matter injury and impact the development of dementia.
methodsHuman chitinase-3-like protein-1 (YKL-40) concentrations at baseline were related to white matter hyperintensity (WMH) volume, free water (FW), and FW-corrected fractional anisotropy using linear effects models (for cross-sectional outcomes) and linear mixed-effects models (for longitudinal outcomes), adjusting for demographic and medical risk factors. Models were repeated with a sex-interaction term and then stratified by sex.
resultsIn stratified analyses, greater baseline YKL-40 concentrations were associated with increased WMHs in females but not males in the parietal (females DISCUSSION: Results suggest that neuroinflammation is a sex-specific driver of WMHs (but not FW) in females. Differential sequelae of neuroinflammation may be one reason that females have a greater burden of WMHs. Highlights: ·Cerebrospinal fluid YKL-40 is associated with white matter hyperintensities in females but not males cross-sectionally and longitudinally.·Longitudinally, cerebrospinal fluid YKL-40 is associated with white matter hyperintensities in the parietal and temporal lobes, regions that exhibit early pathological changes in Alzheimer's disease .·Cerebrospinal fluid YKL-40 is not associated with white matter microstructural measures.
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