Evidence map›Paper›PMID 40352632›Full record

ReviewGlobal challenges (Hoboken, NJ)2025

Silver Nanoparticle-Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review.

Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero

Abstract readReview
In one paragraph

Review in Global challenges (Hoboken, NJ), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ekaterine MosidzeDepartment of Pharmaceutical Technology 33 Vazha-Pshavela Ave Tbilisi 0178 Georgia.
Gianluigi FranciDepartment of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Via S. Allende 43 Baronissi 84081 Italy.
Federica Dell'AnnunziataDepartment of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Via S. Allende 43 Baronissi 84081 Italy.
Nicoletta CapuanoDepartment of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Via S. Allende 43 Baronissi 84081 Italy.
Marica ColellaMicrobiology and Virology Unit, Interdisciplinary Department of Medicine University of Bari "Aldo Moro" Piazza G. Cesare 11 Bari 70124 Italy.
Flora SalzanoDepartment of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Via S. Allende 43 Baronissi 84081 Italy.
Massimiliano GaldieroDepartment of Experimental Medicine University of Campania "Luigi Vanvitelli" Naples Italy.
Aliosha BakuridzeDepartment of Pharmaceutical Technology 33 Vazha-Pshavela Ave Tbilisi 0178 Georgia.
Veronica FollieroDepartment of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno Via S. Allende 43 Baronissi 84081 Italy.ORCID https://orcid.org/0000-0002-7406-9882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infections continue to pose a significant challenge to global health, with increasing resistance to conventional antiviral therapies highlighting the urgent need for alternative treatment strategies. Silver nanoparticles (AgNPs) have attracted attention as broad-spectrum antiviral agents due to their unique physicochemical properties and ability to target multiple stages of viral infection. This review provides a comprehensive analysis of the antiviral mechanisms of AgNPs, highlighting their efficacy against clinically relevant enveloped viruses such as influenza, herpes simplex, hepatitis B, and coronaviruses. How key nanoparticle characteristics, including size, shape, surface functionalization, and synthesis methods, influence their antiviral performance is examined. Studies indicate that AgNPs exert their effects through direct interactions with viral particles, inhibition of viral adhesion, and entry into host cells with disruption of viral replication. Furthermore, their potential applications in therapeutic formulations, antiviral coatings, and nanomedicine-based strategies are explored. Despite their promise, challenges regarding cytotoxicity, stability, and large-scale production must be addressed to ensure their safe and effective clinical use. This review highlights the transformative potential of AgNPs in antiviral therapy and highlights the need for further investigation to facilitate their clinical translation in the fight against emerging and drug-resistant viral infections.

Indexed as

antiviral activitysilver nanoparticlesviral diseasesviral infectionvirus

Identifiers

PMID40352632
PMCPMC12065099

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.