SynthesisFrontiers in pediatrics2025
Determining the optimal contrast-enhanced voiding urosonography technique for vesicoureteral reflux in children and adolescents: a systematic review and network meta-analysis.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Predictive value of ultrasound findings for high-grade vesicoureteral reflux in children: a retrospective cross-sectional study in Saudi Arabia.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To evaluate diagnostic combinations of imaging modalities and contrast agents for vesicoureteral reflux (VUR) in children. Methods: Studies were retrieved in PubMed, EMBASE, Cochrane Library, Web of science, and China National Knowledge Infrastructure (CNKI) until March 16, 2023. We used bivariate random-effects model and a frequentist model for meta-analysis. Surface under the cumulative ranking curve (SUCRA) was used to rank ceVUS protocols. Results: 19 studies identified 4 diagnostic combinations. Contrast-harmonic ultrasound with SonoVue® (CHSV) had significantly lower sensitivity, specificity, and diagnostic accuracy than VCUG, although its negative predictive value was higher than VCUG. Contrast-harmonic ultrasound with Optison™ (CHOS) was comparable to VCUG across all diagnostic measures. SUCRA analysis favored CHOS, with probabilities of being the best for SEN, SPE, PPV, NPV, DOR, and DA at 50.9%, 16.6%, 42.6%, 57.4%, 36.2%, and 20.4%, respectively. Conclusion: Harmonic VUS with Optison™ may be the optimal protocol for VUR detection in children. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023424510, identifier (CRD42023424510).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.