Evidence map›Paper›PMID 40352587›Full record

ArticleFrontiers in oncology2025

Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study.

Jakob Wieke, Christina Jurcic, Adam Kaczorowski, Sarah Böning, Martina Kirchner, Constantin Schwab, Viktoria Schütz, Markus Hohenfellner, Anette Duensing, Albrecht Stenzinger and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jakob WiekeMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Christina JurcicMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Adam KaczorowskiMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Sarah BöningMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Martina KirchnerInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Constantin SchwabInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Viktoria SchützDepartment of Urology, University Hospital Heidelberg, and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Markus HohenfellnerDepartment of Urology, University Hospital Heidelberg, and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Anette DuensingPrecision Oncology of Urological Malignancies, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Albrecht StenzingerInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Stefan DuensingMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Renal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in Methods: A total of 23 RCCs were analyzed by panel next-generation sequencing followed by immunohistochemistry for five functional proxies for key genetic alterations including the expression of CD31, GLUT1, phospho-mTOR S2448, H3K36me3 and Ki-67. Antibody stainings were scored semiquantitatively in the tumor periphery and the tumor center. Results: Unexpectedly, the presence of a Conclusion: This proof-of-concept study adds genotype-phenotype heterogeneity as additional layer of complexity to the known genomic and functional ITH in RCC.

Indexed as

genotypemTORphenotyperenal cell carcinomaSETD2tumor heterogeneityVHL

Identifiers

PMID40352587
PMCPMC12061699

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