Evidence map›Paper›PMID 40352549›Full record

ArticleACS omega2025

Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia.

Georgios Pantouris, Leepakshi Khurana, Pathricia Tilstam, Alison Benner, Thomas Yoonsang Cho, Martin Lelaidier, Mathieu Perrée, Zoe Rosenbaum, Lin Leng, Francine Foss and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Generation of MIF Peptides via Solid Phase Peptide Synthesis.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Georgios PantourisDepartment of Chemistry, University of the Pacific, Stockton, California 95211, United States.ORCID https://orcid.org/0000-0001-5547-1406
Leepakshi KhuranaDepartment of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06510, United States.
Pathricia TilstamDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Alison BennerDepartment of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06510, United States.
Thomas Yoonsang ChoDepartment of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06510, United States.
Martin LelaidierDiatech Oncology, Montreal, Quebec H3A 0G1, Canada.
Mathieu PerréeDiatech Oncology, Montreal, Quebec H3A 0G1, Canada.
Zoe RosenbaumDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Lin LengDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Francine FossHematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, Connecticut 06510, United States.
Vineet BhandariDivision of Neonatology, Department of Pediatrics, The Children's Regional Hospital at Cooper, Camden, New Jersey 08103, United States.
Amit VermaAlbert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461, United States.
Richard BucalaDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Elias J LolisDepartment of Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06510, United States.ORCID https://orcid.org/0000-0002-7902-7868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage migration inhibitory factor (MIF) is a key modulator of innate and adaptive immunity that has been extensively reported to promote tumor cell survival, proliferation, and metastasis. A recent study focusing on the microenvironment of acute myeloid leukemia (AML) showed that pharmacological inhibition of MIF signaling,

Identifiers

PMID40352549
PMCPMC12059935

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.