ArticleACS omega2025
Membrane-Active Peptides Derived from Natural Transmembrane Domains Function as Antibiotic Potentiators.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
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Abstract
Antimicrobial resistance continues to be a prevailing threat to human health worldwide, largely due to the arsenal of resistance mechanisms bacteria have evolved over years of exposure to traditional antibiotics. As an approach to devising therapeutics that can overcome this resistance, we hypothesized that peptides consisting of single transmembrane (TM) segments of membrane proteins may permeabilize bacterial membranes and thereby facilitate access of antimicrobials to their cytoplasmic targets. Using peptides derived from a natural TM helix from the AcrB component of the AcrAB-TolC efflux protein, we found that AcrB TM8 (wild type sequence: KKKK-FL(Abu)LAALYESWSI-NH
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