ArticleACS omega2025
Soyasaponin-I Attenuates Melanogenesis through Activation of ERK and Suppression of PKA/CREB Signaling Pathways.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- α2,3-Sialyltransferase (ST3Gal1) regulates endometrioid-type epithelial ovarian cancer cell migration and invasion via VEGF-R2/JAK2/STAT3 signaling cascades.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- A novel role of erythropoietin in skin pigmentation through melanin production.Scientific reports · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soyasaponin-I (SS-I), a sialyltransferase inhibitor naturally found in soybeans, has antioxidant, anticarcinogenic, and hepatoprotective properties. In this study, we explored the possibility to use SS-I as an antimelanogenic agent for the treatment of skin hyperpigmentation disorders. When melanoma cell lines, MNT-1 and B16F10, were treated with SS-I, significant suppression of both α-2,3 and α-2,6 sialylations was observed by using lectin fluorescence staining with sialic acid-binding lectins-
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Registered trials
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