Evidence map›Paper›PMID 40352523›Full record

ArticleACS omega2025

Proteomic Insights into IgA Nephropathy: A Comprehensive Analysis of Differentially Expressed Proteins in the Kidney.

Jingxian Huang, Hongguo Zhu, Shanshan Li, Jing Qiu, Hougang Yang, Fengping Zheng, Zhifeng Luo, Qiang Yan, Fanna Liu, Lianghong Yin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingxian HuangInstitute of Kidney Disease and Blood Purification, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.ORCID https://orcid.org/0009-0002-1562-2032
Hongguo ZhuInstitute of Kidney Disease and Blood Purification, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Shanshan LiClinical Medical Research Center, The Second Clinical Medical College, Jinan University, Shenzhen People' s Hospital, Shenzhen 518020, China.
Jing QiuClinical Medical Research Center, The Second Clinical Medical College, Jinan University, Shenzhen People' s Hospital, Shenzhen 518020, China.
Hougang YangComprehensive Health Industry Research Center, Taizhou Research Institute, Southern University of Science and Technology, Taizhou 317000, China.
Fengping ZhengInstitute of Kidney Disease and Blood Purification, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.ORCID https://orcid.org/0000-0002-6065-3500
Zhifeng LuoInstitute of Kidney Disease and Blood Purification, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Qiang YanDepartment of Organ Transplantation, The 924th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Guilin 541002, China.
Fanna LiuInstitute of Kidney Disease and Blood Purification, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Lianghong YinInstitute of Kidney Disease and Blood Purification, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.ORCID https://orcid.org/0000-0002-5005-5304
Donge TangClinical Medical Research Center, The Second Clinical Medical College, Jinan University, Shenzhen People' s Hospital, Shenzhen 518020, China.ORCID https://orcid.org/0000-0001-7011-196X
Yong DaiClinical Medical Research Center, The Second Clinical Medical College, Jinan University, Shenzhen People' s Hospital, Shenzhen 518020, China.ORCID https://orcid.org/0000-0002-6840-9158

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA nephropathy represents a significant challenge in nephrology research, and an understanding of its underlying molecular mechanisms is crucial. In this study, we conducted a comprehensive proteomic investigation of IgA nephropathy utilizing microdissection techniques combined with data-independent acquisition technology. Our analysis focused on differentially expressed proteins in the glomeruli, interstitium, and tubules of the kidney. Functional enrichment analysis revealed distinct pathway enrichment patterns, with fatty acid synthesis predominating in the glomerulus and complement and coagulation pathways predominantly enriched in the tubules. These pathway enrichments suggest potential key contributors to the pathogenesis of IgA nephropathy. Furthermore, our study identified ATP1B1 and COX4I1 in the glomerulus and SLC22A13 in the tubules as promising diagnostic markers for the disease. Meanwhile, C4A and APEX1 proteins were identified as valuable biomarkers for assessing disease progression. This research could provide valuable insights into the proteomic alterations associated with IgA nephropathy and offer potential targets for further therapeutic exploration.

Identifiers

PMID40352523
PMCPMC12059920

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.