Evidence map›Paper›PMID 40352508›Full record

ArticleACS omega2025

Pulmonary Injury Induced via Metal-Organic Frameworks (MOFs): ROS Generation and Inflammatory Responses Mediated by HKUST-1.

Yule Zhang, Zhiwei Xue, Zhijin Yang, Mengya Chen, Lianchen Zhou, Lizan Zhou, Mingming Zhu, Zhaofeng Huang, Yuhao Li, Shifei Kang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yule ZhangEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Zhiwei XueEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Zhijin YangEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Mengya ChenEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.ORCID https://orcid.org/0000-0002-2252-6068
Lianchen ZhouEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Lizan ZhouEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Mingming ZhuEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Zhaofeng HuangEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
Yuhao LiSchool of Materials and Chemistry, Institute of Bismuth, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID https://orcid.org/0000-0001-7146-8645
Shifei KangDepartment of Environmental Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China.ORCID https://orcid.org/0000-0002-3145-4430
Lulu ZhengEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.ORCID https://orcid.org/0009-0001-3049-5046
Dawei ZhangEngineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.ORCID https://orcid.org/0000-0002-0841-7826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Owing to their tunable structural and functional characteristics, innovative materials known as metal-organic frameworks (MOFs) have become a research focus in scientific communities, demonstrating significant potential across biomedical applications, including targeted drug delivery, tumor detection technologies, and sophisticated medical imaging diagnostics. Despite the growing interest in their therapeutic potential, the systemic and pulmonary toxicity of MOFs remains inadequately explored, particularly about the long-term effects of metal ion release during degradation. This study investigates the pulmonary toxicity of three widely studied MOFs, UiO-66, ZIF-8, and HKUST-1, focusing on the mechanisms of oxidative stress and inflammation. The in vitro and in vivo assays demonstrated that HKUST-1 induced significant cytotoxicity, oxidative stress, and apoptosis in lung cells, primarily due to its copper content. In contrast, UiO-66 and ZIF-8 exhibited minimal toxicity. These results emphasize the essential requirement for understanding the toxicological profiles of MOFs and highlight the necessity of modifying their structure to enhance safety for biomedical applications.

Identifiers

PMID40352508
PMCPMC12059943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.