ArticleJournal of oral biology and craniofacial research
Effects of different curcumin concentrations on human periodontal ligament fibroblast adhesion and proliferation on periodontally involved root surfaces: In-vitro study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Multifunctional Silk Fibroin-Curcuminoid Films Combining Regenerative and Antioxidant Properties with pH Sensing for Wound Dressing Applications.Biomimetics (Basel, Switzerland) · 2026Article
- Co-Formulation of Iron Oxide and PLGA Nanoparticles to Deliver Curcumin and IFNα for Synergistic Anticancer Activity in A375 Melanoma Skin Cancer Cells.Pharmaceutics · 2025Article
- Polyphenolic compounds in combating MDR periodontal pathogens: current research and future directions.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Periodontopathic endotoxins infiltrate root surface and prevent cellular adhesion to tooth surfaces. Naturally occurring curcumin has anti-inflammatory, antioxidant and antibacterial qualities that promote fast wound healing by increasing fibroblast cell proliferation and migration in concentration-dependent manner. Objectives: This study was conducted to evaluate the effect of 0.12 %, 1 % and 2 % curcumin concentrations on PDL cell adhesion, viability and proliferation to periodontally affected root surfaces. Materials and methods: 20 periodontally affected teeth sectioned into root samples were included. PDL fibroblasts were collected from freshly extracted teeth, cultured and expanded. PDL fibroblast (1 × 10 Results: G3 showed highest viability and cell proliferation compared to other groups where well defined multilayered adherent cells covering entire surface with totally flat polyhedral bodies with long cytoplasmic extensions and little or no bacterial colonization. Conclusion: Curcumin 2 % provides optimal stimulation of cellular attachment, viability, proliferation and antibacterial effects over periodontitis affected root surfaces. Clinical relevance: Determination of optimal curcumin concentration in this study revealed 2 % concentration produced highest levels of PDL cellular attachment, viability, proliferation and antibacterial action over root surfaces afflicted by periodontitis. Therefore, the use of that optimal curcumin concentration as adjunctive to non-surgical periodontal therapy may modify the periodontal pocket ecology to improve the healing of periodontal tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.