ArticleJournal of oral biology and craniofacial research
Exploring the biological activity and setting dynamics of a novel polydopamine-based root repair material.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Comprehensive evaluation of antibacterial activity, pH stability, and surface characterization of a mussel-inspired polymer for root perforation repair.Frontiers in dental medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Root perforation represents a significant complication in endodontics, compromising the structural integrity of the tooth. Effective repair are critical to mitigating the associated risks and preserving long-term dental function. Despite extensive research, the ideal repair material that fulfills all requisite biological and mechanical properties remains elusive. Methodology: This study introduces a novel polydopamine based repair material designed to address the limitations of existing materials. The material was characterized using field emission scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, transmission electron microscopy, zeta potential, and particle size analysis. The material's initial and final setting times were evaluated using a Gilmore needle apparatus. Biocompatibility was assessed via the MTT assay, while bioactivity was quantified through calcium ion release analysis. Comparative evaluations were conducted against ProRoot MTA, a commercially available standard in root repair. Results: The findings revealed no statistically significant differences in cytotoxicity (P > 0.05) between the experimental material and ProRoot MTA, affirming the biocompatibility of both. However, the experimental material demonstrated a significantly faster set (P < 0.001) than ProRoot MTA, a critical advantage in clinical applications. the inclusion of calcium chloride and bioactive glass enhanced calcium ion release, with the experimental material showing significantly higher levels at 7 days. Conclusion: The polydopamine-bioactive glass composite exhibited favorable biological activity, superior setting dynamics, and enhanced bioactivity, positioning it as a promising candidate for perforation repair. These results lay the groundwork for further research and potential clinical translation, offering a viable solution to a longstanding challenge in endodontics.
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Registered trials
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