Observational studyFrontiers in endocrinology2025
Effect of diabetes mellitus on physical function in patients with osteoarthritis: a cross-sectional observational study.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Association between gallstones and arthritis in U.S. adults: A cross-sectional NHANES study.Preventive medicine reports · 2026Article
- Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarthritis (OA) is a common chronic disease among the elderly, causing pain, functional limitations, and a decline in quality of life. Diabetes mellitus (DM), a prevalent metabolic disorder, has been proven to have an association with OA. However, the specific impact of DM on the physical function of OA patients remains lack of in-depth exploration. This study aims to investigate whether OA patients with DM (DMOA) experience more severe physical function limitations. Method: The study utilized National Health and Nutrition Examination Survey (NHANES) data from 1999-2018. Logistic regression models were used to analyze the association between DMOA and physical function limitations. Stratified analysis was applied to assess the stability of these results. Results: DMOA patients exhibited significantly worse physical function compared to those OA patiants who do not complicated with DM (non-DMOA), especially in high-intensity and frequent joint use activities like walking long distances (OR = 1.870, 95%CI[1.243,2.814], Conclusion: This study revealed that the DMOA population has worse physical function than non-DMOA population, especially in high-intensity and frequent joint use activities. Managing DM in OA patients is crucial to improve their physical function and overall quality of life. The impact of DM should be considered in the selection of therapeutic agents and care for OA.
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