ArticleRSC advances2025
Long-term postoperative treatment of open fractures using
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Open fracture surgery is one of the common emergency procedures in orthopedics. It requires effective postoperative management, including anti-inflammatory and antimicrobial measures, as well as promotion of bone cell growth. Due to the higher risk of infection and challenges in fracture healing associated with open fractures, the development of effective long-acting postoperative therapeutic drug delivery materials is crucial. In this study, we demonstrate the development of one spontaneous administration for the postoperative maintenance and treatment of open fractures. By integrating medicine-loaded mesoporous molecular sieves (MMMSs) with hydrogels, a composite material termed nanoporous medicine composite hydrogel (NMCH) was formulated. Through adjusting the proportions of hydrogel monomers and molecular sieves, this material attained mechanical properties akin to periosteum. Physicochemical studies including XRD, SEM, TEM, UV absorption, and N
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