ArticleAlzheimer's & dementia (New York, N. Y.)
The relationship between neurofilament light chain and depressive symptoms according to cognitive status.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The relationship between neurofilament light chain and depressive symptoms according to cognitive status.Alzheimer's & dementia (New York, N. Y.)Article
- P-tau181 is longitudinally associated with a proxy measure of mild behavioral impairment among frail older adults: Insights from COGFRAIL.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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8 authors.
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Abstract
introductionAlthough recent studies have suggested a positive association between plasma neurofilament light chain (NfL) and depressive symptoms, the moderating effect of cognitive performance on this relationship remains unclear. The aim of this study was to investigate the association between NfL and depressive symptoms in a population of community-dwelling older adults and to determine whether cognitive status could modify this relationship.
methodsThis is a secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT), including 512 individuals (60.2% women) with a median age of 76 years (interquartile range [IQR]: 7) and with available data for plasmatic NfL levels. Depressive symptoms and cognitive status were assessed using the 15-item Geriatric Depression Scale (GDS-15) and the Clinical Dementia Rating (CDR) scale, respectively. Multivariable linear regression analyses were conducted to explore the cross-sectional association between GDS-15 (dependent variable) and plasma NfL levels (pg/mL). The interaction between CDR status (binary: 0 or 0.5) and NfL levels in relation to depressive symptoms was also examined, followed by exploratory simple-slope analyses according to CDR status.
resultsNo significant association was observed between GDS-15 scores and plasma NfL levels ( DISCUSSION: NfL levels were not significantly associated with GDS-15 in a population of community-dwelling older adults without dementia. Although no significant CDR-NfL interaction was detected, exploratory analyses suggest that plasma NfL might be associated with GDS-15 scores only among people with a CDR 0.5 (indicative of mild cognitive impairment). Further studies with larger sample sizes are needed to elucidate the potential biological differences in depressive symptoms across different cognitive statuses. Highlights: Plasma neurofilament light (NfL) levels might be associated with 15-Geriatric Depression Scale (GDS-15) scores only among people with Clinical Dementia Rating (CDR) 0.5 (indicative of mild cognitive impairment [MCI]), but not among those with CDR 0 (normal cognition).Depressive symptoms arising in the context of cognitive impairment may represent a distinct clinical entity compared to those observed in individuals with normal cognitive functioning.Further research with larger sample sizes is needed to elucidate potential biological differences in depressive symptoms across varying cognitive statuses (unimpaired cognition, MCI, and dementia).
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