Evidence map›Paper›PMID 40352249›Full record

SynthesisNarra J2025

Effective probiotic regimens for bacterial vaginosis treatment and recurrence prevention: A systematic review.

Udjianto Udjianto, Noorhamdani A Sirat, Bambang Rahardjo, Lilik Zuhriyah

Abstract readSystematic Review
In one paragraph

Synthesis in Narra J, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The Gut-Vagina Axis.Microorganisms · 2026
    Review
  4. Article
  5. HPV vaccination associates withFrontiers in microbiology · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Udjianto UdjiantoDoctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Noorhamdani A SiratDepartment of Clinical Microbiology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
Bambang RahardjoDepartment of Obstetrics and Gynecology, Dr. Saiful Anwar Hospital, Malang, Indonesia.
Lilik ZuhriyahDepartment of Environmental Health Sciences and Health Promotion, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics represent a promising alternative therapy for bacterial vaginosis; however, consensus on the most effective species, strains, and doses remains lacking, and long-term safety data are limited. The aim of this study was to evaluate the effectiveness of probiotics in managing bacterial vaginosis, considering species, strain, clinical outcomes, optimal dosage, duration, and side effects. This study included randomized-controlled trials (RCTs) published in English (2014-2024) on probiotic treatment for bacterial vaginosis, assessing species, strain, dose, duration, and efficacy. A systematic search was conducted on December 20, 2024, in Scopus, Web of Science, and PubMed using the keywords "vaginosis," "bacterial vaginosis," and "probiotic." Data were extracted and synthesized, and study quality was assessed using the Risk of Bias 2 tool, while NVivo 14 software facilitated thematic analysis. The systematic search yielded 1,560 initial records, of which 16 RCTs were included. The findings revealed that

Indexed as

ProbioticsSecondary PreventionVaginosis, BacterialFemaleHumansLacticaseibacillus rhamnosusRandomized Controlled Trials as TopicTreatment OutcomeVaginaalternative therapiesBacterial vaginosisprobioticsvaginal diseaseswomen's health

Identifiers

PMID40352249
PMCPMC12059960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.