Evidence map›Paper›PMID 40352195›Full record

SynthesisNarra J2025

Exploring the role of polysaccharides in mitigating organ damage caused by pesticide-induced toxicity: A systematic review and meta-analysis of in vivo studies.

Elly N Sakinah, Nurud Diniyah, Achmad Subagio, Ancah Cn Marchianti, Jauhar Firdaus, Stela S Fambudi, Stefia A Amini, Dhiani E Putri

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Narra J, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Investigating the cardioprotective effects ofBiochemistry and biophysics reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elly N SakinahDepartment of Pharmacology, Faculty of Medicine, Universitas Jember, Jember, Indonesia.
Nurud DiniyahDepartment of Agricultural Products Technology, Faculty of Agricultural Technology, Universitas Jember, Jember, Indonesia.
Achmad SubagioDepartment of Agricultural Products Technology, Faculty of Agricultural Technology, Universitas Jember, Jember, Indonesia.
Ancah Cn MarchiantiDepartment of Public Health, Faculty of Medicine, Universitas of Jember, Jember, Indonesia.
Jauhar FirdausDepartment of Physiology, Faculty of Medicine, Universitas Jember, Jember, Indonesia.
Stela S FambudiFaculty of Medicine, Universitas Jember, Jember, Indonesia.
Stefia A AminiFaculty of Medicine, Universitas Jember, Jember, Indonesia.
Dhiani E PutriFaculty of Medicine, Universitas Jember, Jember, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although polysaccharides have demonstrated potential in alleviating dysbiosis, the overall impact of polysaccharides on minimizing oxidative stress and organ damage in vivo has not been thoroughly investigated. The aim of this study was to investigate the comprehensive effects of polysaccharides in mitigating pesticide toxicity in animal studies, focusing on biomarkers related to oxidative stress, antioxidant activity, kidney injury, lipid profiles, liver function, and the preservation of liver and kidney weights. A systematic search was conducted across nine indexed databases, including PubMed, Cochrane CENTRAL, Taylor & Francis, Scopus, Sage, EBSCO, ProQuest, ScienceDirect, and Google Scholar. Rayyan.ai was used to screen in vivo studies that met the predefined inclusion and exclusion criteria. The quality of the selected in vivo studies was evaluated using SYRCLE's Risk of Bias tool, specifically designed for animal studies. Thirteen randomized animal studies, comprising 330 mice and rats, were included in the analysis. The findings revealed that polysaccharides significantly increased antioxidant levels, including catalase (CAT) (

Indexed as

Oxidative StressPesticidesPolysaccharidesAnimalsAntioxidantsBiomarkersKidneyLiverMiceRatsAntioxidantsBiomarkersPesticidesPolysaccharidesDysbiosisgut microbiotaoxidative stresspesticidepolysaccharides

Identifiers

PMID40352195
PMCPMC12059844

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.