Evidence map›Paper›PMID 40352149›Full record

ArticleFrontiers in physiology2025

Age- and sex-specific reference values for CT-based low skeletal muscle quantity and quality in healthy living kidney donors.

David Martin, Paola Dolce, Martin Hübner, Tobias Zingg, David Fuks, Jean-Pierre Venetz, Damien Maier, Maurice Matter, Fabio Becce

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Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David MartinDepartment of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Paola DolceDepartment of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Martin HübnerDepartment of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Tobias ZinggDepartment of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
David FuksDepartment of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Jean-Pierre VenetzDepartment of Transplantation, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Damien MaierDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Maurice MatterDepartment of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Fabio BecceDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Computed tomography (CT) imaging is a useful tool for assessing skeletal muscle mass and quality. The present study aimed to determine age- and sex-specific reference values for CT-based skeletal muscle markers in a healthy population, and to correlate them with serum creatinine and 24-h urinary creatinine excretion (24h-UCE). Methods: Skeletal muscle index (SMI) - a marker of muscle mass/quantity - and skeletal muscle radiation attenuation (SMRA) and intermuscular adipose tissue index (IMATI) - markers of muscle quality/myosteatosis - were determined using a deep-learning-based method from axial CT images at the level of the 3 Results: CT scans of 394 healthy individuals were included. The mean age was 53 years (SD 12), mean BMI was 25.2 kg/m Conclusion: The age- and sex-specific reference values reported here could be used in clinical practice and future studies to identify patients at risk of muscle decline.

Indexed as

computed tomographyliving kidney donormuscle massmuscle qualitymyosteatosis

Identifiers

PMID40352149
PMCPMC12061965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.