ArticleFrontiers in physiology2025
Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
Introduction: The aim of this research is to elucidate chronic obstructive pulmonary disease (COPD) progression by quantifying lung ventilation heterogeneities using single-photon emission computed tomography (SPECT) images and establishing correlations with quantitative computed tomography (qCT) imaging-based metrics. This approach seeks to enhance our understanding of how structural and functional changes influence ventilation heterogeneity in COPD. Methods: Eight COPD subjects completed a longitudinal study with three visits, spaced about a year apart. CT scans were performed at each visit and qCT-based variables were derived to measure the structural and functional characteristics of the lungs, while the SPECT-based variables were used to quantify lung ventilation heterogeneity. The correlations between key qCT-based variables and SPECT-based variables were examined. Results: The SPECT-based ventilation heterogeneity (CV Discussion: In conclusion, this study found strong positive cross-sectional correlations between CV
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