Evidence map›Paper›PMID 40352065›Full record

ArticleAlpha psychiatry2025

BDNF Gene Polymorphism and Antidepressant Response in Han Chinese Patients with First-Episode Late-Life Depression.

Han Wu, Jiao-Jiao Zhou, Xue-Yan Chen, Dan-di Zhu, Feng Bao, Wei Zheng, Li Ren, Wei-Gang Pan, Chao-Meng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alpha psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Potential value of oral Mogibacterium in major depressive disorder.Frontiers in cellular and infection microbiology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Han WuBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0000-0002-7091-7303
Jiao-Jiao ZhouBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0000-0002-0095-1995
Xue-Yan ChenBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0009-0008-2731-1323
Dan-di ZhuBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0000-0001-9205-4302
Feng BaoBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0009-0009-3933-8010
Wei ZhengDepartment of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, 510370 Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-2371-4789
Li RenBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0009-0002-7914-3380
Wei-Gang PanPeking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, 100096 Beijing, China.ORCID https://orcid.org/0009-0003-9572-6786
Chao-Meng LiuBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0000-0002-2461-4723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study investigated the association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and antidepressant response in patients with first-episode late-life depression (LLD). Methods: A total of 72 patients with first-episode LLD were recruited and 57 completed an 8-week course of antidepressant treatment. Participants were assessed at baseline and post-treatment using the 17-item Hamilton Depression Rating Scale (HAMD-17) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum BDNF levels were measured via Enzyme-Linked Immunosorbent Assay (ELISA) and BDNF gene polymorphisms were genotyped using the Agena® MassARRAY system. Results: After 8 weeks, 17 of the 57 patients with LLD showed effective treatment response (effective group), while 40 were classified as ineffective. Significant post-treatment improvements were observed across the cohort in HAMD-17 and RBANS scores, and serum BDNF levels compared with baseline ( Conclusion: Antidepressant treatment for 8 weeks altered serum BDNF levels in patients with LLD, with male patients carrying the Clinical Trial Registration: The study was registered at https://www.chictr.org.cn (registration number: ChiCTR1900024445).

Indexed as

antidepressantsdepressionmood disorders

Identifiers

PMID40352065
PMCPMC12059767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.