ArticleTherapeutic advances in musculoskeletal disease2025
Muscle health in ankylosing spondylitis: effects of disease duration, inflammation, education level, and spinal mobility on skeletal muscle atrophy.
Article in Therapeutic advances in musculoskeletal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Vertebral Ankylosis Is Associated with Reduced Cervical Extensor Muscle Bulk and Increased Fatty Degeneration.Journal of clinical medicine · 2025Article
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13 authors.
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Abstract
Background: Ankylosing spondylitis (AS) is a progressive chronic disease that primarily affects the axial skeleton, leading to significant musculoskeletal impairment. This condition may extend its inflammatory impact to peripheral muscles, potentially resulting in muscle wasting. Objectives: The study aimed to investigate the prevalence of sarcopenia among AS patients, to determine the specific cutoff values for muscle status, and to identify risk factors that may impact muscle status in AS patients. Design: A cross-sectional study was conducted involving consecutive AS patients attending the Department of Rheumatology and Immunology at the First Medical Center of the Chinese PLA General Hospital. Clinical characteristics and body composition were evaluated. Methods: Based on the Asian Working Group for Sarcopenia criteria, the prevalence of sarcopenia among AS patients were calculated. Additionally, specific cutoff values for muscle mass and muscle strength in AS patients were analyzed. Univariable and multivariable logistic regression analyses were employed to scrutinize risk factors impacting muscle status in AS patients, including appendicular skeletal muscle mass index (ASMI) and grip strength. Results: Measurements of body composition, including ASM at 22.79 kg and ASMI at 7.69 kg/m², were significantly lower compared to the healthy control group ( Conclusion: Our study indicates that AS patients may have a diminished muscle status. Although the incidence of sarcopenia among AS patients is relatively low, a notable subset does suffer from muscle atrophy. Variables such as disease duration, education level, inflammatory markers, and BASMI are likely to influence muscle status in AS patients, warranting consideration in clinical management and intervention strategies.
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