ReviewCureus2025
The Role of Anesthesia in Sedation and Weaning From Mechanical Ventilation: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical ventilation is a critical component of care in ICUs, yet its prolonged use can result in significant complications. Effective sedation strategies play a pivotal role in facilitating the discontinuation of mechanical ventilation and minimizing associated adverse outcomes. This systematic review evaluates the impact of anesthetic-based sedation methods on optimizing the process of weaning adult patients from mechanical ventilation in intensive care settings. A comprehensive literature search was conducted across major databases, including PubMed, Web of Science, Scopus, the Virtual Health Library, and Cochrane CENTRAL, up to March 10, 2024, following established systematic review guidelines. Eligible studies included randomized controlled trials and observational research comparing anesthetic agents with conventional sedation techniques, with outcomes such as weaning duration, extubation success, length of stay in the ICU, incidence of delirium, sedation quality, adverse events, and mortality. Study quality was assessed using a validated methodological checklist. Out of 1,649 records screened, five studies met the inclusion criteria. Results indicated that dexmedetomidine was associated with shorter weaning times and reduced anxiety, agitation, and delirium compared to traditional sedation. Sequential sedation protocols, particularly transitions from midazolam to dexmedetomidine, yielded improved clinical outcomes, while enteral methadone significantly reduced weaning duration compared to fentanyl. Despite higher daily costs, anesthetic agents demonstrated favorable economic outcomes due to shorter intensive care stays. These findings suggest that targeted anesthetic sedation strategies may enhance the weaning process and improve overall patient outcomes, underscoring the need for further large-scale studies to validate and standardize these approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.