ArticleCureus2025
Multimodal Management of Complex Congenital Heart Disease: A Case of Atrial and Ventricular Septal Defects With a Bifid Apex.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bifid Cardiac Apex in Noonan Syndrome: An Unusual Cardiac Morphology Associated with a RAF1 Pathogenic Variant.Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital heart disease (CHD) is one of the most common congenital anomalies influenced by both genetic and environmental factors. Atrial septal defect (ASD) and ventricular septal defect (VSD) are among the most common types of CHD. ASD is more common in females and often remains asymptomatic during childhood, leading to delayed diagnosis. Both surgical and percutaneous closure techniques are used, with evidence supporting early intervention for improved outcomes. This study presents the case of a female patient with CHD, including ASD, VSD, and a bifid left ventricular apex, who was treated with both surgical and percutaneous approaches. The patient underwent open heart surgery for ASD closure at the age of 17 years. Eight years later, residual ASD and VSD were identified, and percutaneous transcatheter closure was performed using closure devices. Post-procedural imaging confirmed successful defect closure, a significant reduction in left-to-right shunting, and a decrease in right ventricular pressure. However, residual mitral valve prolapse and moderate mitral regurgitation persisted, requiring ongoing monitoring. The presence of a bifid apex in this patient adds a unique anatomic consideration to managing CHD. While typically considered a benign variant, its association with other structural abnormalities requires careful evaluation. Future management strategies should include detailed imaging studies, such as cardiac MRI, to assess long-term ventricular function and detect potential complications. This case highlights the importance of a comprehensive, multimodal management strategy that includes surgical and transcatheter techniques for complex coronary artery disease cases. Regular follow-up with echocardiography and cardiac MRI is essential to monitor residual defects, assess ventricular function, and ensure long-term treatment success. Early detection and timely intervention are critical to optimizing patient outcomes, preventing complications, and improving quality of life.
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Registered trials
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