ArticleCureus2025
An Unusual Case of H3K27-Altered Diffuse Midline Glioma Presenting as a Third Ventricular Mass.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Diffuse Midline Gliomas: Clinical, Diagnostic, and Therapeutic Perspectives.Biomedicines · 2026Review
- Diffuse midline glioma, H3K27-altered, mimicking central neurocytoma on MRI: A case report.Radiology case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse midline gliomas (DMGs) are rare central nervous system tumors, typically arising from astrocytes. The H3K27-altered DMG subtype is defined by a specific histone protein mutation that disrupts normal cellular regulation and promotes unchecked proliferation. Due to their aggressive nature, the World Health Organization (WHO) universally classifies these as grade IV, regardless of histological appearance. While DMGs are most commonly described in pediatric populations and overwhelmingly originate in the pons, their occurrence and clinical progression in adults remain underexplored. This report highlights a rare presentation of an H3K27-altered DMG, presenting as a third ventricular mass in a 30-year-old man, emphasizing its atypical location and the challenges it presents for diagnosis and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.