ArticleCureus2025
Comparison of Ultrasonography and Scintigraphy as Localization Techniques in the Preoperative Evaluation of Primary Hyperparathyroidism.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Incidence of Ectopic Parathyroid Glands in Primary, Secondary, and Tertiary Hyperparathyroidism.The Journal of surgical research · 2026Article
- Predicting Failure of Conventional Imaging in Primary Hyperparathyroidism: The Impact of Parathyroid Hormone Levels and Thyroid Nodules.The Eurasian journal of medicine · 2026Article
- Clinical and Biochemical Correlates of Parathyroid Gland Burden in Patients Undergoing Parathyroidectomy for Secondary Hyperparathyroidism: A Retrospective Observational Study.Journal of clinical medicine · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary hyperparathyroidism (pHPT) is the most common endocrine disorder responsible for hypercalcemia in non-hospitalized patients. When indicated for parathyroidectomy for pHPT, preoperative imaging is recommended to localize the affected parathyroid glands, including neck ultrasonography and 99m-Tc-sestaMIBI scintigraphy. The aim of this study was to investigate and compare the findings obtained by ultrasonography and scintigraphy in the preoperative evaluation. A retrospective review was conducted on all patients who underwent partial parathyroidectomy for a diagnosis of pHPT between January 2022 and December 2024 in a specialized center in Mexico. The locations according to scintigraphy and ultrasound were compared using the McNemar test, and specificity, sensitivity, negative predictive value (NPV), and positive predictive value (PPV) were determined. A significant difference was observed only in the case of non-localization of affected glands (p<0.0001). For scintigraphy, sensitivity was 100%, specificity 60.70%, PPV 73.7%, and NPV 100%. For ultrasonography, sensitivity was 60%, specificity 87.5%, PPV 93.2%, and NPV 25.93%. The concordance observed between the preoperative localization findings obtained by 99m-Tc-sestaMIBI scintigraphy and ultrasonography in patients with pHPT highlights the enduring value of ultrasonography as a preoperative tool, due to its accessibility and cost-effectiveness.
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