Evidence map›Paper›PMID 40351868›Full record

ArticleBioinformatics advances2025

PPIFold: a tool for analysis of protein-protein interaction from AlphaPullDown.

Quentin Rouger, Emmanuel Giudice, Damien F Meyer, Kévin Macé

Abstract read
In one paragraph

Article in Bioinformatics advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Quentin RougerUniv. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR)-UMR6290, Rennes 35000, France.
Emmanuel GiudiceUniv. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR)-UMR6290, Rennes 35000, France.
Damien F MeyerCIRAD, UMR ASTRE, Petit-Bourg, Guadeloupe 97170, France.ORCID https://orcid.org/0000-0003-2735-176X
Kévin MacéUniv. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR)-UMR6290, Rennes 35000, France.ORCID https://orcid.org/0000-0002-9853-0565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: Protein structure and protein-protein interaction (PPI) predictions based on coevolution have transformed structural biology, but managing pre-processing and post-processing can be complex and time-consuming, making these tools less accessible. Results: Here, we introduce PPIFold, a pipeline built on the AlphaPulldown Python package, designed to automate file handling and streamline the generation of outputs, facilitating the interpretation of PPI prediction results. The pipeline was validated on the bacterial Type 4 Secretion System nanomachine, demonstrating its effectiveness in simplifying PPI analysis and enhancing accessibility for researchers. Availability and implementation: PPIFold is implemented as a pip package and available at: https://github.com/Qrouger/PPIFold.

Identifiers

PMID40351868
PMCPMC12064169

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.