ArticleFood science and biotechnology2025
Gromwell (
Article in Food science and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Sarcopenia, an age-related disease characterized by the loss of skeletal muscle mass and function, is a growing concern in the aging population. This study investigated the potential of Gromwell (Lithospermum erythrorhizon, LE) to ameliorate sarcopenia in aged mice and the effect of lithospermic acid (LA), a bioactive compound found in LE, on cellular senescence in aged human skeletal muscle myoblast (HSMM) cells. Nineteen-month-old male C57BL/6 mice were fed a diet supplemented with 0.05% LE for 9 weeks. LE supplementation mitigated age-related loss of muscle mass and function, promoted the transition of muscle fiber type from type I to type II, and reduced markers associated with muscle atrophy. In vitro, LA treatment decreased β-galactosidase activity and senescence marker expression in senescent HSMM cells. These findings suggest that LE may serve as a valuable food resource for the prevention and mitigation of sarcopenia, with LA contributing to its effectiveness.
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