ArticleJournal of orthopaedic case reports2025
Occult Papillary Carcinoma Thyroid with Solitary Appendicular Bone Metastasis in Proximal Humerus - A Case Report.
Article in Journal of orthopaedic case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: An occult presentation of primary thyroid malignancy refers to a clinically silent primary tumor that initially manifests through metastasis or secondary paraneoplastic phenomena. Papillary carcinoma is a well-recognized thyroid malignancy associated with this pattern of presentation, but bone metastases are uncommon in occult papillary thyroid carcinoma (OPTC), with reported cases typically involving the axial skeleton. Case Report: A woman in her 70s presented with swelling and pain in her right arm. Examination revealed an oval swelling on the proximal humerus. Radiographs and magnetic resonance images suggested a lytic lesion in the proximal humerus. Upon metastatic workup, biopsy, and immunohistochemistry, the diagnosis turned out to be metastasis from occult papillary thyroid cancer. Conclusion: Bone metastases are uncommon in OPTC, with reported cases typically involving the axial skeleton. Metastasis to the appendicular skeleton as the initial presentation is exceptionally rare.
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