ArticleOncology letters2025
Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Composite lymphoma containing both B-cell lymphoma and extranodal natural killer/T-cell lymphoma (ENKTL) is extremely rare. Clonal evolution and tumor microenvironment (TME) features have not been reported previously. The present study reports one case of the heterochronous occurrence of follicular lymphoma (FL) and ENKTL and one case of the simultaneous occurrence of diffuse large B-cell lymphoma (DLBCL) and ENKTL. The results of targeted DNA sequencing demonstrated the genetic features and dynamic clonal evolution of each component. Notably, in the case of ENKTL secondary from FL, predominant clones harbored in ENKTL were already present at the initial diagnosis of FL and expanded to full clonal prevalence afterward in ENKTL. In the case of synchronous DLBCL and ENKTL, predominant clones in ENKTL were exclusive to those clones dominating in DLBCL. Multiple immunofluorescence and CIBERSORT analyses depicted TME features and showed that CD68
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