Evidence map›Paper›PMID 40351559›Full record

ArticleAesthetic surgery journal. Open forum2025

Needle-Free Jet Injectors and Their Potential Applications in Plastic Surgery: A Review.

Neil M Vranis, Spero Theodorou

Abstract read
In one paragraph

Article in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Neil M Vranis
Spero Theodorou

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Needle-free jet injector (NFJI) devices offer an alternative to traditional needle-syringe injection for administration of medications, vaccines, and other fluids. They are already in clinical use around the world for vaccines and insulin administration. NFJIs have reproducibly demonstrated improvement in speed of drug absorption and efficacy; however, this technology has yet to prevail in the plastic surgery industry. Plastic surgeons have experimented with this technology to inject botulinum toxin for palmar hyperhidrosis, steroids for keloids/hypertrophic scars, and local anesthesia. A review was conducted to identify studies published in the last 10 years, indexed on PubMed, involving NFJI devices. Original articles that included ex vivo experimentation, animal studies, and human trials were included. Review articles, mathematical modeling theoretical articles, and nonmedical applications of jet injectors were excluded. A total of 767 identified articles were screened. Once exclusion criteria were applied, there were 115 articles remaining. The majority of the studies were conducted on human patients ( Level of Evidence 3 Therapeutic:

Identifiers

PMID40351559
PMCPMC12065001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.