Evidence map›Paper›PMID 40351387›Full record

ArticleBrain communications2025

White matter tract correlations with spoken language in cerebrovascular disease.

Dana N Broberg, Seyyed M H Haddad, Katharine Aveni, Alexander Havens, Paula M McLaughlin, Malcolm A Binns, Joseph B Orange, Stephen R Arnott, Courtney Berezuk, Leanne K Casaubon and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Dana N BrobergDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 3K7, Canada.ORCID https://orcid.org/0000-0001-6595-2270
Seyyed M H HaddadCentre for Functional & Metabolic Mapping, Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 3K7, Canada.
Katharine AveniRoxelyn & Richard Pepper Department of Communication Sciences & Disorders, Northwestern University, Evanston, IL 60201, USA.
Alexander HavensRoxelyn & Richard Pepper Department of Communication Sciences & Disorders, Northwestern University, Evanston, IL 60201, USA.
Paula M McLaughlinNova Scotia Health, Halifax, NS B3S 0H6, Canada.
Malcolm A BinnsRotman Research Institute, Baycrest, Toronto, ON M6A 2E1, Canada.
Joseph B OrangeSchool of Communication Sciences & Disorders, Western University, London, ON N6G 1H1, Canada.
Stephen R ArnottIndoc Systems, Toronto, ON M5H 3W4, Canada.
Courtney BerezukHarvard Medical School, Mass General Brigham, Boston, MA 02115, USA.
Leanne K CasaubonDepartment of Medicine (Neurology), University of Toronto, Toronto, ON M5S 3H2, Canada.
Dar DowlatshahiDepartment of Medicine (Neurology), University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON K1H 8M5, Canada.
Ayman HassanNorthern Ontario School of Medicine University, Thunder Bay, ON P7B 5E1, Canada.
Nuwan D NanayakkaraCentre for Functional & Metabolic Mapping, Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 3K7, Canada.
Alicia J PeltschSmith Engineering, Queen's University, Kingston, ON K7L 3N6, Canada.
Joel RamirezDr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.ORCID https://orcid.org/0000-0002-5582-1776
Gustavo SaposnikDepartment of Medicine (Neurology), University of Toronto, Toronto, ON M5S 3H2, Canada.
Christopher J M ScottSunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Richard H SwartzDepartment of Medicine (Neurology), University of Toronto, Toronto, ON M5S 3H2, Canada.
Sean SymonsDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada.
Angela K TroyerNeuropsychology & Cognitive Health Program, Baycrest, Toronto, ON M6A 2E1, Canada.ORCID https://orcid.org/0000-0001-5660-4127
ONDRI Investigators
Angela C RobertsSchool of Communication Sciences & Disorders, Western University, London, ON N6G 1H1, Canada.
Robert BarthaDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 3K7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of spoken language is a promising marker for cognitive impairment in individuals with cerebrovascular disease. However, the underlying neurological basis for spoken language beyond single words and sentences remains poorly defined in this cohort, particularly with respect to white matter. This study aimed to examine and compare white matter hyperintensity volumes and diffusion tensor metrics in normal-appearing white matter (NAWM) as potential correlates of spoken language performance. Baseline imaging and spoken language data were obtained from the cerebrovascular disease cohort of the Ontario Neurodegenerative Disease Research Initiative (

Indexed as

cerebrovascular diseasediffusion tensor imaginglanguagemagnetic resonance imagingwhite matter

Identifiers

PMID40351387
PMCPMC12062522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.